Recombinant Human Tau K18/Tau PHF Core Protein, CF Summary
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins.Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration.The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard.In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
SP-496
| Formulation | X mg/ml (XμM) in PBS pH 7.4 |
| Shipping | The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
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Reconstitution Calculator
Background: Tau
Tau is a microtubule-associated protein expressed primarily in neurons. Carboxy-terminal domains of Tau associate with and stabilize microtubule structure, while other domains bind to the plasma membrane. Abnormal Tau phosphorylationmay result in the self-assembly of tangles of paired helical and/or straight filaments, which are involved in the pathogenesis of Alzheimer"s disease and other neurodegenerative diseases. Properly folded Tau is highly soluble, but when the protein becomes misfolded it forms insoluble aggregates that can damage cytoplasmic functions, interfere with axonal transport and ultimately lead to cell death. This recombinant protein is untagged and consists of amino acids 243-372 of UniProt # P10636-8.
- Billingsley M.L. & Kincaid R.L.(1997) Biochem. J. 323:577
- Bloom G.S. (2014) JAMA Neurol. 71: 505
- Cripps D. et al.(2006) J. Biol. Chem. 281: 10825
- Harada A. et al (1994) Nature 369: 488
- Lei P. et al. (2010) Int. J. Biochem. Cell Biol. 42: 1775
- Shamas S.L. et al. (2015) Nat. Comm. doi: 10.1038/ncomms8025
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