Adipogen/anti-Ubiquitin K48 Linkage, mAb (1001c)/AG-20T-0209-C050/50 µg

来自 : 发布时间：2024-05-12

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UBB; Ubiquitin B

Monoclonal Antibody

1001c

Rabbit IgG

K48-linkage from human ubiquitin.

Western Blot: (0.1-0.5µg/ml)

AllHuman

Recognizes endogenous human proteins containing K48-linked polyubiquitin chains, but has no cross-reactivity to monoubiquitin or polyubiquitin of other linkages.

Protein A purified.

Liquid. In PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.

Manufactured by Boston Biochem

BLUE ICE

+4°C

-20°C

Aliquot to avoid freeze/thaw cycles.

Stable for at least 1 year after receipt when stored at -20°C.

No

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Polyubiquitin chains are composed of ubiquitin monomers that are covalently linked through isopeptide bonds (other than linear, or \"Met1-linked” polyubiquitin). Isopeptides are formed between a lysine residue of one ubiquitin molecule and the C-terminal glycine residue of another ubiquitin molecule. Seven of the seventy-six amino acids in ubiquitin are lysine residues that can participate in polyubiquitin chain formation. Linkage through specific lysine residues is thought to serve as a signal that affects protein degradation, signaling, trafficking, and other cellular processes. K48-linked polyubiquitin chains attached to substrate proteins often serve as a recognition sequence for targeting and destruction of the substrate by the 26S proteasome.